Hideous creatures descend on Manhattan. Ground reports from the squad tasked with containing the pandemonium refer to these life forms as the Twisted. An investigatory team known as the CTI is formed within the year.
Aya is the main focus of this game. Due to her special powers, she still has the body of a woman in her 20s, although in terms of age she should actually be 39 years old. Motomu Toriyama, the scenario director, feels that it is rare to be able to focus on a woman in her 30s in a game and is taking the opportunity to properly depict the thinking and lifestyle of a cool woman. Square Enix announced the title at their 2007 party in Japan for the gaming press. A promotional teaser has also been released which shows Aya in wedding garb.