She is a classmate and friend of Ichigo Kurosaki, the main character of the series. Like many other friends of Ichigo, she quickly develops spiritual powers of her own after Ichigo becomes a Soul Reaper.
Orihime Inoue is a long-time classmate of Ichigo, linked to him by mutual friend Tatsuki Arisawa. She her elder brother Sora ran away from their abusive parents at a young age, and her brother later died. Though initially devoid of spiritual powers, she begins to develop spiritual awareness and later obtains one of the most powerful healing abilities in the Bleach universe, able to completely restore a body to its previous state regardless of how severely it is wounded. It is not technically a healing ability, however. She has the ability to "reject" what happened to an object or area, making it as if nothing ever happened.